Functional Ingredients

Bactistatin (Active Metabolites Extract of B. subtilis strain 3 (B-2335)

Therapeutic Segment – Gastrointestinal Health

Production Technology (API) – Fermentation of Bacillus Subtilis Strain 3 (B-2335)

Followed by extraction and drying of Cell free culture medium.

Dosage Form – Capsules

Innovator – Kraft Group LLC, Russia

Mechanism of Action

Bactistatin ( Active Metabolite Extract of B. subtilis strain B-2335) which is a first in class “Metabiotic” eliminates the need for the first three steps of conventional probiotics -

(i) Survival of the strain

(ii) Adhesion to Intestinal Epithelium and

(iii) Colonization and provides the Metabolites destined to be produced subsequently in the gut in a ready to ingest form. Further, providing a cell free extract of approved probiotic as a dietary supplement effectively address the predictable challenges associated with probiotic formulations:

i. Every probiotic strain has a peculiar nutrient medium requirement for keeping it alive throughout its shelf life,
ii. Temperature and moisture requirements of the probiotic to stay viable throughout shelf life.
iii. Any kind of Stress including mechanical stress during lyophilization and packing the strain in a capsule may adversely affect its probiotic-ability and overall viability.
iv. Usage issues with anti-biotics

Indications

Bactistatin has been evaluated for various diseases pertaining to Gastrointestinal Health including Irritable Bowel Syndrome, Celiac Disease, Dysbiotic Disorders, Chemotherapy induced dysbiois, correction of microbiocenosis, correction of neuroendocrine homeostasis of colon.